Referred Work

From 1/3/18 renin samples are analysed using the IDS iSYS direct renin mass immunoassay which will use the following reference ranges:

Ambulatory:  Female: 6.1 – 62.7 mIU/L,  Male: 9.0 – 103 mIU/L

Supine: 4.2 – 59.7 mIU/L

For interpretation of the aldosterone:renin ratio in the context of hypertension please see Figure 1 in Primary Aldosteronism: An Endocrine Society Clinical Practice Guideline | The Journal of Clinical Endocrinology & Metabolism | Oxford Academic. 

(Endocrine guidelines on the investigation of Conns https://doi.org/10.1210/jc.2015-4061)

The Aldosterone/Renin ratio cut-off that we are providing is a guide only and not a diagnostic test and the ratio should be interpreted, cautiously, in conjunction with relevant clinical information and medications that may affect the ratio.

Early morning range (7-9 a.m.): 3.2-22.8 nmol/L

Late night range (11 p.m. to 12 a.m.): <3.2 nmol/L

Provided by reference laboratory

Provided by referral laboratory

Please note from 13 Feb 2017 new reference ranges and tests reported for TMA profile. TMA/TMA-n-oxide result has been replaced by % N-oxidation.  Dimethylamine is no longer routinely analysed as part of the TMA profile - if it is required it should be requested separately.

PLEASE NOTE FROM JANUARY 2018 TOTAL TMA/CREATININE RATIO WILL NO LONGER BE REPORTED.  The parameter is not directly required for diagnosis and is an assessment of the amount of dietary choline going through the pathway, which aids in the interpretation of results.  The parameter will still be measured but not reported, rather a comment will be added if the value is low indicating insufficient stressing of the pathway which could lead to a false negative.  

<0.5 umol/L

Normal values <2 nmol/mmol creatinine

Normal range:

< 5 μmol/mol creatinine
< 5 μg/24 hr
< 85 nmol/24 hr

Reference ranges provided by referral laboratory (July 2014).

NB: Results are expressed as nmol bone collagen equivalent (BCE)/mmol creatinine.

Reference ranges provided by referral laboratory (July 2014).  All ranges expressed as nmol/mmol creatinine.