Toxicology

Therapeutic use of methadone is typically associated with plasma concentrations of 0.05 to 1.0 mg/L dependent on the dose, with adverse drug reactions being noted in the region of 1 to 2 mg/L for regular users of the drug. (Clarke's Analysis of Drugs & Poisons, Third Edition). 

Please contact the laboratory for interpretaion.

Toxicity associated with midazolam levels > 1.0 mg/L. (Schulz et al. Critical Care 2012, 16:R136).

Please contact the laboratory if midazolam measurement is required for therapeutic monitoring purposes.

Morphine concentrations > 50 µg/L associated with toxicity. However, interpretation is dependent on the concentrations of metabolites. (Baselt, Disposition of Toxic Drugs and Chemicals in Man, Eighth Edition, 2008).

Please contact the laboratory for further interpretation. 

Units ug/L

Please contact the laboratory for guidance in therapy 

Please contact the laboratory if oxycodone measurement is required for therapeutic monitoring purposes.

Therapeutic range = 20 - 65 ug/L

Please contact the laboratory if paroxetine measurement is required for therapeutic monitoring purposes.

Paroxetine is measured by LC-MS/MS.

Therapeutic range: 2 – 5 mg/L

(Source: Schulz et al. Critical Care 2012, 16:R136)

Therapeutic range: 0.02 - 0.3 mg/L.  Toxicity associated with concentrations > 1.0 mg/L.  (Schulz et al. Critical Care 2012, 16:R136).